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賴盈如助理教授 Ying-Ju Lai , Ph. D.
 
     
聯絡資訊
聯絡電話:(032118800分機5229
主要學歷
德國基森大學生命科學博士
現職
長庚大學呼吸治療學系助理教授
經歷
美國史丹佛大學心血管研究中心博士後研究員(2009/8-2010/9
德國基森大學心肺研究中心 博士後研究員(2008/10-2009/6
財團法人工研院藥物傳輸技術部副研究員(2003/10-2004/09
 
研究專長
肺動脈高壓基礎研究、分子生物、細胞生物學
授課科目
分子生物學、呼吸照護專題實作、分子生物技術實驗
近年論文發表
    *期刊論文

1. YJ Lai,*, HH Hsu, GJ Chang, SH Lin, WJ Chen; CC Huang; JHS. Pang*. Prostaglandin E1 Attenuates Pulmonary Artery Remodeling by Activating Phosphorylation of CREB and the PTEN Signaling Pathway. Scientific Reports. 2017. (SCI: 4.259)

2. Tojais NFCao ALai YJWang LChen PIAlcazar MAAde Jesus Perez VHopper RKRhodes CJBill MASakai LYRabinovitch M. Codependence of Bone Morphogenetic Protein Receptor 2 and Transforming Growth Factor-β in Elastic Fiber Assembly and Its Perturbation in Pulmonary Arterial Hypertension. Arterioscler Thromb Vasc Biol. 2017 Aug;37(8):1559-1569. (SCI: 6.609)

3. WJ Chen YH Chen, YJ Lai, YJ Hsu, YH YehCS Tsai, CY Lin. GT-repeat length polymorphism in heme oxygenase-1 promoter determines the effect of cilostazol on vascular smooth muscle cells. Int J Cardiol. 2016 Nov 1;222:407-15. (SCI: 6.189)

4. YJ Lai, GJ Chang, YH Yeh, JH S. Pang, CC Huang, WJ Chen3*, Propylthiouracil Attenuates Experimental Pulmonary Hypertension via Suppression of Pen-2, a Key Component of Gamma-Secretase. PLoS ONE 10(9): e0137426. (SCI: 2.806)

5. Yeh YH, Kuo CT, Chang GJ, Chene YH, Lai YJ, Cheng ML, Chen WJ, Rosuvastatin suppresses atrial tachycardia-induced cellular remodeling via Akt/Nrf2/heme oxygenase-1 pathway. J Mol Cell Cardio 82 (2015) 84–92. (SCI: 5.68)

6. H Sawada, T Saito, N P Nickel, TP Alastalo, JP Glotzbach, R Chan, L Haghighat, G Fuchs, M Januszyk, A Cao, YJ Lai, V de Jesus Perez, YM Kim, Ll Wang, PI Chen, E Spiekerkoetter, Y Mitani, GC Gurtner, P Sarnow, M Rabinovitch. Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension. J. Exp. Med. 2014. 211 (2) 263-280. (SCI: 11.991)

7. Wu YH, Chuang SY, Hong WC, Lai YJ, Chang YL, Pang JH. In vivo and in vitro inhibitory effects of a traditional Chinese formulation on LPS-stimulated leukocyte-endothelial cell adhesion and VCAM-1 gene expression. J Ethnopharmacol. 2012 Mar 6; 140(1): 55-63. (SCI: 2.981)

8. Y-H. Wu, S-Y. Chuang, W-C. Hong, Y-J. Lai, G-J. Chang and J-H.S.Pang. Berberine reduces leukocyte adhesion to LPS-stimulated endothelial cells and VCAM-1 expression both in vivo and in vitro. Int J Immunopathol Pharmacol 2012 Vol. 25, no. 4 (SCI: 2.347)

9. De Jesus Perez V, Z Ali, TP Alastalo, F Ikeno, H Sawada, YJ Lai, T Kleisli, E Spiekerkoetter, X Qu, LH Rubinos, E Ashley, M Amieva, S Dedhar and M Rabinovitch. Bone Morphogenetic Protein Promotes Motility and Represses Proliferation of Vascular Smooth Muscle Cells by Tandem Recruitment of Wnt Pathways. J Cell Biol 2011; 192:171-188 (SCI, IF 7.955, cell biology ranking: 15/156, cited 21)

10. Dahal BK, Kosanovic D, Pamarthi PK, Sydykov A, Lai YJ, Kast R, Schirok H, Stasch JP, Ghofrani HA, Weissmann N, Grimminger F, Seeger W, Schermuly RT. Therapeutic Efficacy Of Azaindole-1 In Experimental Pulmonary Hypertension. Eur Respir J 2010 Jun 7 (SCI, IF 10.569, Respiratory system ranking: 3/40)

11. Lai YJ, Pullamsetti SS, Dony E, Weissmann N, Butrous G, Banat GA, Ghofrani HA, Seeger W, Grimminger F, Schermuly RT. Role of the prostanoid EP4 receptor in iloprost-mediated vasodilatation in pulmonary hypertension. Am J Respir Crit Care Med. 2008 Jul 15; 178(2):188-96. (SCI, IF 13.204, Respiratory system ranking: 1/40)

12. Dony E, Lai YJ, Dumitrascu R, Pullamsetti SS, Savai R, Ghofrani HA, Weissmann N, Schudt C, Flockerzi D, Seeger W, Grimminger F, Schermuly RT. Partial reversal of experimental pulmonary hypertension by phosphodiesterase 3/4 inhibition. Eur Respir J. 2008 Mar;31(3):599-610. (SCI, IF 10.569, Respiratory system ranking: 3/40, cited 19)

13. Schermuly RT, Dony E, Ghofrani HA, Pullamsetti S, Savai R, Roth M, Sydykov A, Lai YJ, Weissmann N, Seeger W, Grimminger F. Reversal of experimental pulmonary hypertension by PDGF inhibition. J Clin Invest. 2005 Oct;115(10):2811-21. (SCI, IF 12.78, medicine, research &experimental ranking 4/111)

14. WJ Chen, KH Lin, YJ Lai, SH Yang, and JH S Pang. Protective Effect of Propylthiouracil Independent of Its Hypothyroid Effect on Atherogensis in Cholesterol-Fed Rabbits: PTEN Induction and Inhibition of Vascular Smooth Muscle Cell Proliferation and Migration Circulation. 2004 Sep 7; 110(10):1313-9. (SCI, IF 19.309, Vascular disease ranking: 1/61)

 

*會議論文

1. YC Chen, HH Li, YJ Lai*. Prostanoid EP4 Analogue Attenuates Experimental Pulmonary Arterial Hypertension Via Activation of PPAR-Gamma Signaling. 美國胸腔科年會Washington 19-24 May, 2017

2. HC Hsu, HH Li, YJ Lai*. The Role of Smooth Muscle Cathepsins in Pulmonary Arterial Hypertension Associated with Systemic Lupus Erythematosus. 美國胸腔科年會San Francisco. 13-18 May, 2016

3. HH Li1, YL Hsieh, YJ Lai*. Effect of L902,688, a potent Prostanoid EP4 receptor agonist, inhibit pulmonary arterial smooth muscle cells proliferation in monocrotaline-induced pulmonary arterial remodeling. 美國胸腔科年會,Denver 15-20 May, 2015.

4. YL Hsieh, YJ Lai*. Cathepsin S degrades the tropoelastin in obliterative pulmonary vascular lesions. 美國胸腔科年會, San Diego, 16-21 May, 2014.

5. YJ Lai, WJ Chen. Mechanism underlying the protective effect of propylthiouracil on pulmonary arterial hypertension. The 7th pulmonary vascular research institute (PVRI) annual general meeting and the 6th PVRI workshops and debates. Istanbul, Turkey 20-25 Jan, 2013.

 

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