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賴盈如助理教授 Ying-Ju Lai , Ph. D.
德國基森大學心肺研究中心 博士後研究員(2008/10-2009/6

1. YJ Lai *, IC Chen, HH Li, CC Huang. EP4 Agonist L-902,688 Suppresses EndMT and Attenuates Right Ventricular Cardiac Fibrosis in Experimental Pulmonary Arterial Hypertension. Int. J. Mol. Sci. 2018, 19, 727; doi:10.3390/ijms19030727. (SCI: 3.226) (116/286, Biochemistry & Molecular Biology)

2. HH Li, HH Hsu, GJ Chang, IC Chen, WJ Ho, PC Hsu, WJ Chen, JHS. Pang, CC Huang, YJ Lai*. Prostanoid EP4 Agonist L-902,688 Activates PPARg and Attenuates Pulmonary Arterial Hypertension. Am J Physiol Lung Cell Mol Physiol 2018, 314: L349–L359, (SCI: 4.28) (10/136, pulmonary and respiratory Medicine).

3. YJ Lai,*, HH Hsu, GJ Chang, SH Lin, WJ Chen; CC Huang; JHS. Pang*. Prostaglandin E1 Attenuates Pulmonary Artery Remodeling by Activating Phosphorylation of CREB and the PTEN Signaling Pathway. Scientific Reports. 2017. (SCI: 4.259) (10/164, Multidsciplinary Sciences)

4. Tojais NFCao ALai YJWang LChen PIAlcazar MAAde Jesus Perez VHopper RKRhodes CJBill MASakai LYRabinovitch M. Codependence of Bone Morphogenetic Protein Receptor 2 and Transforming Growth Factor-β in Elastic Fiber Assembly and Its Perturbation in Pulmonary Arterial Hypertension. Arterioscler Thromb Vasc Biol. 2017 Aug;37(8):1559-1569. (SCI: 6.609) (16/344, Cardiology And Cardiovascular Medicine)

5. WJ Chen YH Chen, YJ Lai, YJ Hsu, YH YehCS Tsai, CY Lin. GT-repeat length polymorphism in heme oxygenase-1 promoter determines the effect of cilostazol on vascular smooth muscle cells. Int J Cardiol. 2016 Nov 1;222:407-15. (SCI: 6.189) (16/126, Cardiac & Cardiovascular Systems)

6. YJ Lai, GJ Chang, YH Yeh, JH S. Pang, CC Huang, WJ Chen3*, Propylthiouracil Attenuates Experimental Pulmonary Hypertension via Suppression of Pen-2, a Key Component of Gamma-Secretase. PLoS ONE, 2015, 10(9): e0137426. (SCI: 3.2) (15/64, Multidisciplinary Sciences)

7. Yeh YH, Kuo CT, Chang GJ, Chene YH, Lai YJ, Cheng ML, Chen WJ, Rosuvastatin suppresses atrial tachycardia-induced cellular remodeling via Akt/Nrf2/heme oxygenase-1 pathway. J Mol Cell Cardio 82 (2015) 84–92. (SCI: 5.68) (20/126, Cardiac & Cardiovascular Systems; 42/190, Cell Biology)

8. H Sawada, T Saito, N P Nickel, TP Alastalo, JP Glotzbach, R Chan, L Haghighat, G Fuchs, M Januszyk, A Cao, YJ Lai, V de Jesus Perez, YM Kim, Ll Wang, PI Chen, E Spiekerkoetter, Y Mitani, GC Gurtner, P Sarnow, M Rabinovitch. Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension. J. Exp. Med. 2014. 211 (2) 263-280. (SCI: 11.991) (7/151, Immunology; 5/128, Medicine, Research & Experimental)

9. D Kosanovic, X Tian, O Pak, YJ Lai, YL Hsieh, M Seimetz, N Weissmann, R T Schermuly, BK Dahal Rhodiola: an ordinary plant or a promising future therapy for pulmonary hypertension? a brief review Pulm Circ. 2013 Sep; 3(3): 499–506. (SCI 2.178) (69/126, Cardiac & Cardiovascular Systems)

10. Wu YH, Chuang SY, Hong WC, Lai YJ, Chang YL, Pang JH. In vivo and in vitro inhibitory effects of a traditional Chinese formulation on LPS-stimulated leukocyte-endothelial cell adhesion and VCAM-1 gene expression. J Ethnopharmacol. 2012 Mar 6; 140(1): 55-63. (SCI: 2.981) (89/257, Pharmacology & Pharmacy)

11. Y-H. Wu, S-Y. Chuang, W-C. Hong, Y-J. Lai, G-J. Chang and J-H.S.Pang. Berberine reduces leukocyte adhesion to LPS-stimulated endothelial cells and VCAM-1 expression both in vivo and in vitro. Int J Immunopathol Pharmacol 2012 Vol. 25, no. 4 (SCI: 2.347) (133/257, Pharmacology & Pharmacy)

12. De Jesus Perez V, Z Ali, TP Alastalo, F Ikeno, H Sawada, YJ Lai, T Kleisli, E Spiekerkoetter, X Qu, LH Rubinos, E Ashley, M Amieva, S Dedhar and M Rabinovitch. Bone Morphogenetic Protein Promotes Motility and Represses Proliferation of Vascular Smooth Muscle Cells by Tandem Recruitment of Wnt Pathways. J Cell Biol 2011; 192:171-188 (SCI: 7.955) (15/156, Cell Biology)

13. Dahal BK, Kosanovic D, Pamarthi PK, Sydykov A, Lai YJ, Kast R, Schirok H, Stasch JP, Ghofrani HA, Weissmann N, Grimminger F, Seeger W, Schermuly RT. Therapeutic Efficacy of Azaindole-1 In Experimental Pulmonary Hypertension. Eur Respir J 2010 Jun 7 (SCI: 10.569) (3/40, Respiratory System)

14. Lai YJ, Pullamsetti SS, Dony E, Weissmann N, Butrous G, Banat GA, Ghofrani HA, Seeger W, Grimminger F, Schermuly RT. Role of the prostanoid EP4 receptor in iloprost-mediated vasodilatation in pulmonary hypertension. Am J Respir Crit Care Med. 2008 Jul 15; 178(2):188-96. (SCI: 13.204) (1/40, Respiratory System)

15. Dony E, Lai YJ, Dumitrascu R, Pullamsetti SS, Savai R, Ghofrani HA, Weissmann N, Schudt C, Flockerzi D, Seeger W, Grimminger F, Schermuly RT. Partial reversal of experimental pulmonary hypertension by phosphodiesterase 3/4 inhibition. Eur Respir J. 2008 Mar;31(3):599-610. (SCI: 10.569) (3/40, Respiratory System)

16. Schermuly RT, Dony E, Ghofrani HA, Pullamsetti S, Savai R, Roth M, Sydykov A, Lai YJ, Weissmann N, Seeger W, Grimminger F. Reversal of experimental pulmonary hypertension by PDGF inhibition. J Clin Invest. 2005 Oct;115(10):2811-21. (SCI: 12.784) (4/111, Medicine, Research &Experimental)

17. WJ Chen, KH Lin, YJ Lai, SH Yang, and JH S Pang. Protective Effect of Propylthiouracil Independent of Its Hypothyroid Effect on Atherogensis in Cholesterol-Fed Rabbits: PTEN Induction and Inhibition of Vascular Smooth Muscle Cell Proliferation and Migration Circulation. 2004 Sep 7; 110(10):1313-9. (SCI: 19.309) (1/61, Vascular Disease)


1. YC Chen, HH Li, YJ Lai*. Prostanoid EP4 Analogue Attenuates Experimental Pulmonary Arterial Hypertension Via Activation of PPAR-Gamma Signaling. 美國胸腔科年會Washington 19-24 May, 2017

2. HC Hsu, HH Li, YJ Lai*. The Role of Smooth Muscle Cathepsins in Pulmonary Arterial Hypertension Associated with Systemic Lupus Erythematosus. 美國胸腔科年會San Francisco. 13-18 May, 2016

3. HH Li1, YL Hsieh, YJ Lai*. Effect of L902,688, a potent Prostanoid EP4 receptor agonist, inhibit pulmonary arterial smooth muscle cells proliferation in monocrotaline-induced pulmonary arterial remodeling. 美國胸腔科年會,Denver 15-20 May, 2015.

4. YL Hsieh, YJ Lai*. Cathepsin S degrades the tropoelastin in obliterative pulmonary vascular lesions. 美國胸腔科年會, San Diego, 16-21 May, 2014.

5. YJ Lai, WJ Chen. Mechanism underlying the protective effect of propylthiouracil on pulmonary arterial hypertension. The 7th pulmonary vascular research institute (PVRI) annual general meeting and the 6th PVRI workshops and debates. Istanbul, Turkey 20-25 Jan, 2013.


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