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Cheng-Ta Yang, MD

















嘉義長庚紀念醫院呼吸治療科主任 (2001~2004, 2005~2007)

嘉義長庚紀念醫院呼吸胸腔科主任 (2005~2009)

嘉義長庚紀念醫院內科部主任 (2003~2009)

林口長庚紀念醫院呼吸胸腔科系主任 (2010~2012)








F12. Cheng-Ta Yang, Jhy-Ming Li, Wing-Keung Chu, Shu-Er Chow*. Downregulation of lumican accelerates lung cancer cell invasion through p120 catenin.Cell Death and Disease 2018 Mar 16; 9(4):414 DOI 10.1038/s41419-017-0212-3. 

A2. Cheng-Ta Yang*; Jhy-Ming Li; Li-Fu Li; Yu-Shien Ko; Jeng-Ting Chen. Stomatin-like Protein 2 Regulates Survivin Expression in Non-Small Cell Lung Cancer Cells through ß-Catenin Signaling Pathway. Cell Death & Disease 2018 Mar 19;9(4):425. doi: 10.1038/s41419-018-0461-9.

K14 Li-Fu Li, Pao-Hsien Chu, Cheng-Yiu Hung, Winston W.-Y. Kao, Meng-Chih Lin, Yung-Yang Liu, Cheng-Ta Yang*. Lumican Regulates Ventilation-Induced Epithelial-Mesenchymal Transition through Extracelluar Signal-Regulated Kinase Pathway. Chest 2013 May;143(5):1252-60. doi: 10.1378/chest.12-2058.

K17 Jhy-Ming Li, Kuo-Chin Kao, Li-Fu Li, Tsung-Ming Yang, Chean-Ping Wu, Yan-Ming Horng, William WG Jia and Cheng-Ta Yang*. MicroRNA-145 regulates oncolytic herpes simplex virus-1 for selective killing of human non-small cell lung cancer cells Virology Journal 2013, 10:241.

K18 Chih-Hsi Kuo, Ching-Yang Wu, Kang-Yun Lee, Shu-Min Lin, Fu-Tsai Chung, Yu-Lun Lo, Chien-Ying Liu, Te-Chih Hsiung, Cheng-Ta Yang*, and Yi-Cheng Wu*. Chronic Obstructive Pulmonary Disease in Stage I Non-small Cell Lung Cancer That Underwent Anatomic Resection: The Role of a Recurrence Promoter. COPD. 2014 Aug;11(4):407-13. doi: 10.3109/15412555.2013.838946. Epub 2014 Jan 29.

K19 Li-Fu Li, Yung-Yang Liu, Kuo-Chin Kao, Chen-Te Wu, Chih-Hao Chang, Chen-Yiu Hung and Cheng-Ta Yang*. Mechanical ventilation augments bleomycin-induced epithelial–mesenchymal transition through the Src pathway. Laboratory Investigation 2014 Sep;94(9):1017-29. doi: 10.1038/labinvest.2014.75. Epub 2014 Jun 23.

K20 Scott Chih-Hsi Kuo, Ping-Chih Hsu, Chih-Hung Chen, Chih-Teng Yu, Chih-Liang Wang, Fu-Tsai Chung, Shu-Min Lin, Yu-Lun Lo, Tse-Ching Chen, Chien-Ying Liu, Cheng-Ta Yang*. Overall Response to First-Line Tyrosine Kinase Inhibitor and Second-Line Chemotherapy Is Predictive of Survival Outcome in Epidermal Growth Factor Receptor-Mutated Adenocarcinoma. Chemotherapy. 2015 Apr 2;60(3):201-210.

K21 Li-Fu Li, Chung-Shu Lee, Yung-Yang Liu, Chih-Hao Chang, Chang-Wei Lin, Li-Chung Chiu, Kuo-Chin Kao, Ning-Hung Chen, Cheng-Ta Yang*. Activation of Src-dependent Smad3 signaling mediates the neutrophilic inflammation and oxidative stress in hyperoxia-augmented ventilator-induced lung injury.  Respiratory Research 2015 2015 Sep 16;16(1):112. doi: 10.1186/s12931-015-0275-6.

K22 Feng-Che Kuan, Shih-Hong Li, Chih-Liang Wang, Meng-Hung Lin, Ying-Huang Tsai, Cheng-Ta Yang*. Analysis of progression-free survival of rst-line tyrosine kinase inhibitors in patients with non-small cell lung cancer harboring leu858Arg or exon 19 deletions. Oncotarget. 2017 Jan 3;8(1):1343-1353. doi: 10.18632/oncotarget.13815.

K23 Li-Fu Li, Kuo-Chin Kao, Yung-Yang Liu, Chang-Wei Lin, Ning-Hung Chen, Chung-Shu Lee, Chih-Wei Wang, Cheng-Ta Yang*. Nintedanib reduces ventilation-augmented bleomycin-induced epithelial–mesenchymal transition and lung fibrosis through suppression of the Src pathway.Journal of Cellular and Molecular Medicine 2017 Nov;21(11):2937-2949. doi: 10.1111/jcmm.13206. Epub 2017 Jun 9.

K24 Shih-Hong Li, Chien-Ying Liu, Ping-Chih Hsu, Yueh-Fu Fang, Chun-Chieh Wang, Kuo-Chin Kao, Li-Chuan Tseng, Cheng-Ta Yang*. Response to afatinib in treatment-naïve patients with advanced mutant epidermal growth factor receptor lung adenocarcinoma with brain metastases.Expert Review of Anticancer Therapy 2017 Dec 2:1-9. doi: 10.1080/14737140.2018.1409623.

K25 Chien-Ying Liu, Chih-Liang Wang, Shih-Hong Li, Ping-Chih Hsu, Chih-Hung Chen, Ting-Yu Lin, Chih-Hsi Kuo, Yueh-Fu Fang, How-Wen Ko, Chih-TengYu, Tai-Yun Yang and Cheng-Ta Yang*. The efficacy of 40 mg versus dose de-escalation to less than 40 mg of afatinib (Giotrif) as the first-line therapy for patients with primary lung adenocarcinoma harboring favorable epidermal growth factor mutations. Oncotarget 2017 Jun 27;8(57):97602-97612. doi: 10.18632/oncotarget.18746. eCollection 2017 Nov 14.

K26 Chih-Hsi Scott Kuo*, Chien-Ying Liu, Stelios Pavlidis, Yu-Lun Lo, Yen-Wen Wang, Chih-Hung Chen, How-Wen Ko, Fu-Tsai Chung, Tin-Yu Lin, Tsai-Yu Wang, Kang-Yun Lee, Yi-Ke Guo, Tzu-Hao Wang and Cheng-Ta Yang*. Unique immune gene expression patterns in bronchoalveolar lavage and tumor adjacent non-neoplastic lung tissue in non-small cell lung cancer. Frontier in Immunology 2018 Feb 12;9:232. doi: 10.3389/fimmu.2018.00232. eCollection 2018.

C62. Chao-Hua Chiu, Cheng-Ta Yang, Jin-Yuan Shih, Ming-Shyan Huang, Wu-Chou Su, Ruay-Sheng Lai, Chin-Chou Wang, Shih-Hsin Hsiao, Yu-Ching Lin, Ching-Liang Ho, Te-Chun Hsia, Ming-Fang Wu, Chun-Liang Lai, Kang-Yun Lee, Chih-Bin Lin, Diana Yu-Wung Yeh, Chi-Yuan Chuang, Fu-Kang Chang, Chun-Ming Tsai, Reury-Perng Perng, James Chih-Hsin Yang*. Epidermal growth factor receptor tyrosine kinase inhibitor treatment response in advanced lung adenocarcinomas with G719X/L861Q/S768I mutations. Journal of Thoracic Oncology 2015 May;10(5):793-9.  

C63. Tsung-Ying Ho, Pai-Chien Chou, Cheng-Ta Yang, Ngan-Ming Tsang and Tzu-Chen Yen*. Total Lesion Glycolysis Determined per RECIST 1.1 Criteria Predicts Survival in EGFR Mutation-Negative Patients With Advanced Lung Adenocarcinoma. Clinical Nuclear Medicine 2015 Jun;40(6):e295-9. doi: 10.1097/RLU.0000000000000774.  

C64. Hsu-Huei Weng, Chih-Feng Chen, Yuan-Hsiung Tsai, Chih-Ying Wu, Meng Lee, Yu-Ching Lin, Cheng-Ta Yang, Ying-Huang Tsai, Chun-Yuh Yang. Gray matter atrophy in narcolepsy: An activation likelihoodestimation meta-analysis.  Neuroscience and Biobehavioral Reviews 2015 Dec;59:53-63. doi: 10.1016/j.neubiorev.2015.03.009.  

C65. Chih-Hao Chang, Kuo-Chien Tsao, Han-Chung Hu, Chung-Chi Huang, Kuo-Chin Kao, Ning-Hung Chen, Cheng-Ta Yang, Ying-Huang Tsai, Meng-Jer Hsieh*. Procalcitonin and C-reactive protein cannot differentiate bacterial or viral infection in COPD exacerbation requiring emergency department visits. International Journal of Chronic Obstructive Pulmonary Disease 2015 Apr 13;10:767-74. doi: 10.2147/COPD.S76740.  

C66. Ying-Huang Tsai*, Meng-Jer Hsieh, Chee-Jen Chang, Yu-Wen Wen, Han-Chung Hu, Yen-Nan Chao, Yhu-Chering Huang, Cheng-Ta Yang, Chung-Chi Huang. The 23-valent pneumococcal polysaccharide vaccine is effective in elderly adults over 75 years old—Taiwan's PPV vaccination program. Vaccine. 2015 Jun 9;33(25):2897-902. doi: 10.1016/j.vaccine.2015.04.068.  

C68. Kuo-Chin Kao*, Han-Chung Hu, Chih-Hao Chang, Chen-Yiu Hung, Li-Chung Chiu, Shih-Hong Li, Shih-Wei Lin, Li-Pang Chuang, Chih-Wei Wang, Li-Fu Li, Ning-Hung Chen, Cheng-Ta Yang, Chung-Chi Huang and Ying-Huang Tsai. Diffuse alveolar damage associated mortality in selected acute respiratory distress syndrome patients with open lung biopsy. Critical Care 2015 May 15;19(1):228. doi:10.1186/s13054-015-0949-y.  

C69. Tse-Hung Huang, Yi-Han Chiu, Yi-Lin Chan, Hang Wang, Tsung-Lin Li, Chien-Yin Liu, Cheng-Ta Yang, Tzung-Yan Lee, Jyh-Sheng You, Kuang-Hung Hsu*, Chang-Jer Wu*. Antrodia cinnamomea alleviates cisplatin-induced hepatotoxicity and enhances chemo-sensitivity of line-1 lung carcinoma xenografted in BALB/cByJ mice. Oncotarget 2015 Sep 22;6(28):25741-54. doi: 10.18632/oncotarget.4348.  

C70. Ching-Yang Wu, Jui-Ying Fu, Ching-Feng Wu, Yun-Hen Liu, Ming-Ju Hsieh, MD, Yi-Cheng Wu, Cheng-Ta Yang and Ying-Huang Tsai*. Pathologic stage of nonsmall cell lung cancer patients presenting as resectable cases after neoadjuvant therapy did not predict the prognosis.Medicine (Baltimore) 2015 Oct;94(40):e1700.  

C71. Feng-Che Kuan, Liang-Tseng Kuo, Min-Chi Chen, Cheng-Ta Yang, Chung-Sheng Shi, David Teng and Kuan-Der Lee*. Overall survival benefits of first-line EGFR tyrosine kinase inhibitors in EGFR-mutated non-small-cell lung cancers: a systematic review and meta-analysis.Britih Journal of Cancer 2015 Nov 17;113(10):1519-1528. doi: 10.1038/bjc.2015.356.  

C72. Jeng-Sen Tseng, Chih-Liang Wang, Tsung-Ying Yang, Chih-Yi Chen, Cheng-Ta Yang, Kun-Chieh Chen, Kuo-Hsuan Hsu, Chi-Ren Tsai, Gee-Chen Chang*. Divergent epidermal growth factor receptor mutation patterns between smokers and non-smokers with lung adenocarcinoma. See comment in PubMed Commons belowLung Cancer 2015 Dec;90(3):472-6.  

C73. Han-Chung Hu, Kuo-Chin Kao, Li-Chung Chiu, Chih-Hao Chang, Chen-Yiu Hung, Li-Fu Li, Tsui-Ping Liu, Lee-Chung Lin, Ning-Hung Chen, Chung-Chi Huang, Cheng-Ta Yang, and Jang-Jih Lu*. Clinical outcomes and molecular typing of heterogenous vancomycin-intermediate Staphylococcus aureus bacteremia in patients in intensive care units. BMC Infectious Diseases. 2015 Oct 23;15:444. doi: 10.1186/s12879-015-1215-2.  

C74. Ming‑Szu Hung*, I‑Chuan Chen, Liang You, David M. Jablons, Ya‑Chin Li, Jian‑Hua Mao, Zhidong Xu, Meng‑Jer Hsieh, Yu‑Ching Lin, Cheng‑Ta Yang, Shih‑Tung Liu, Ying‑Huang Tsai. Knockdown of Cul4A increases chemosensitivity to gemcitabine through upregulation of TGFBI in lung cancer cells. Oncololgy Reports. 2015 Dec;34(6):3187-95.  

C75. Ching-Yang Wu, MD, Jui-Ying Fu, Ching-Feng Wu, Ming-Ju Hsieh, Yun-Hen Liu, Yi-Cheng Wu, Cheng-Ta Yang, and Ying-Huang Tsai. Survival Prediction Model Using Clinico-Pathologic Characteristics for Non-small Cell Lung Cancer Patients After Curative Resection.Medicine (Baltimore). 2015 Nov;94(45):e2013. doi: 10.1097/MD. 0000000000002013.  

C76. MingSzu Hung*, IChuan Chen, Liang You, David M. Jablons, YaChin Li, JianHua Mao, Zhidong Xu, JrHau Lung, ChengTa Yang, and ShihTung Liu. Knockdown of cullin 4A inhibits growth and increases chemosensitivity in lung cancer cells. Journal of Cellular and Molecular Medicine. 2016 Jul; 20(7): 1295–1306.  

C77. Yu-Lee Dai, Cheng-Ta Yang, Kang-Hua Chen, Siew-Tzuh Tang*. Changes in and Determinants of Quality of Life in Patients With Advanced Non-Small-Cell Lung Cancer Undergoing Initial Chemotherapy.Journal of Nursing Research 2017 Jun;25(3):203-215. doi: 10.1097/JNR.0000000000000148.  

C78. Chia-Cheng Tseng, Chin-Chou Wang, Chang-Chun Hsiao, Hung-I Lu, Steve Leu, Huang-Chih Chang, Kuo-Tung Huang, Wen-Feng Fang, Yu-Mu Chen, Shih-Feng Liu, Cheng-Ta Yang, Meng-Chih Lin, Hon-Kan Yip*. Time courses and value of circulating microparticles in patients with operable stage non-small cell lung cancer undergoing surgical intervention. Tumor Biology. 2016 Apr 8. 2016 Sep;37(9):11873-11882.  

C79. Kung-Chu Ho, Yu-Hua Dean Fang, Hsiao-Wen Chung, Yuan-Chang Liu, John Wen-Cheng Chang, Ming-Mo Hou, Cheng-Ta Yang, Nai-Ming Cheng, Tzu-Pei Su, Tzu-Chen Yen*. TLG-S criteria are superior to both EORTC and PERCIST for predicting outcomes in patients with metastatic lung adenocarcinoma treated with erlotinib.European Journal of Nuclear Medicine and Molecular Imaging. 2016 Nov;43(12):2155-2165.  

C80. Ning-Hung Chen*, Yu-Ting Chou, Pei-Hsien Lee, Shih-Wei Lin, Li-Pang Chuang, Yu-Sheng Lin and Cheng-Ta Yang. Reversibility of albuminuria and continuous positive airway pressure compliance in patients of obstructive sleep apnea syndrome. Medicine (Baltimore). 2016 Jun;95(26):e4045. doi: 10.1097/MD. 0000000000004045.  

C81. Ping-Chih Hsu, Li-Chung Chiu, Shih-Hong Li, Chih-Hung Chen, Chih-Liang Wang, Kuo-Chin Kao, John Wen-Chang Chang, Chih-Wei Wang, Chih-Teng Yu, Fu-Tsai Chung, Cheng-Ta Yang, Chien-Ying Liu*. Continuous epidermal growth factor receptor-tyrosine kinase inhibitor administration in primary lung adenocarcinoma patients harboring favorable mutations with controlled target lung tumors dose not hinder survival benefit despite small new lesions.Biomedical Journal. 2016 Apr;39(2):121-9. doi: 10.1016/ Epub 2016 Jun 9.

C82. Ping-Chih Hsu, Bin You, Yi-Lin Yang, Wen-Qian Zhang, Yu-Cheng Wang, Zhidong Xu, Yuyuan Dai, Shu Liu, Cheng-Ta Yang, Hui Li, Bin Hu, David M. Jablons, Liang You*. YAP promotes erlotinib resistance in human non-small cell lung cancer cells.Oncotarget. 2016 Aug 9;7(32):51922-51933. doi: 10.18632/oncotarget.10458.  

C83. Kuo-Hsuan Hsu, Jeng-Sen Tseng, Chih-Liang Wang, Tsung-Ying Yang, Chien-Hua Tseng, Hsuan-Yu Chen11, Kun-Chieh Chen, Chi-Ren Tsai, Cheng-Ta Yang, Sung-Liang Yu, Kang-Yi Su, Chong-Jen Yu, ChaoChi Ho, Te-Chun Hsia, Ming-Fang Wu, Kuo-Liang Chiu, Chien-Ming Liu, Pan-Chyr Yang, Jeremy J.W. Chen, Gee-Chen Chang*. Higher frequency but random distribution of EGFR mutation subtypes in familial lung cancer patients.Oncotarget. 2016 Aug 16;7(33):53299-53308. doi: 10.18632/oncotarget.10715.  .

C84. Chen-Ping Hsieh, Ming-Ju Hsieh, Ching-Feng Wu, Jui-Ying Fu, Yun-Hen Liu, Yi-Cheng Wu, Cheng-Ta Yang, Ching-Yang Wu. Prognostic factors in non-small cell lung cancer patients who received neoadjuvant therapy and curative resection.Journal of Thoracic Disease. 2016 Jul;8(7):1477-86. doi: 10.21037/jtd.2016.05.57.  

C85. Tai-Long Chen, John Wen-Cheng Chang, Chih-Liang Wang, Cheng-Ta Yang, Mei-Chia Wang, Chiuan-Chian Chiou. A primer and probe set for detecting multiple types of EGFR exon 19 deletions. Analytical Biochemistry. 2016 Sep 4;513:61-67. doi: 10.1016/j.ab.2016.09.002.  

C86. Li-Pang Chuang, Shih-Wei Lin, Li-Ang Lee, Hsueh-Yu Li, Chih-Hao Chang, Kuo-Chin Kao, Li-Fu Li, Chung-Chi Huang, Cheng-Ta Yang, Ning-Hung Chen. The gender difference of snore distribution and increased tendency to snore in women with menopausal syndrome: a general population study. Sleep Breath. 2016 Dec 23. doi: 10.1007/s11325-016-1447-4.  

C87. Chun-Yu Lin, Wei-Lun Liu, Che-Chia Cha, Hou-Tai Chang, Han-Chung Hu, Kuo-chin Kao, Ning-Hung Chen, Ying-Jen Chen, Cheng-Ta Yang, Chung-Chi Huang* and George Dimopoulos. Invasive fungal tracheobronchitis in mechanically ventilated critically ill patients: underlying conditions, diagnosis, and outcomes.Annals of Intensive Care 2017 Jan;7(1):9. doi: 10.1186/s13613-016-0230-9.  

C88. Shih-Hong Li, Bor-Shing Lin, Chen-Han Tsai, Cheng-Ta Yang and Bor-Shyh Lin*. Design of wearable breathing sound monitoring system for real-time wheeze detection. Sensors (Basel). 2017 Jan 17;17(1). pii: E171. doi: 10.3390/s17010171.  

C89. Ming-Szu Hung*, I-Chuan Chen, Paul-Yann Lin, Jr-Hau Lung, Ya-Chin Li, Yu-Ching Lin, Cheng-Ta Yang and Ying-Huang Tsai*. Epidermal growth factor receptor mutation enhances expression of vascular endothelial growth factor in lung cancer.Oncology Letters 2016 Dec; 12(6): 4598–4604.   

C90. Li‑Chung Chiu*, Han‑Chung Hu, Chen‑Yiu Hung, Chih‑Hao Chang, Feng‑Chun Tsai, Cheng‑Ta Yang, Chung‑Chi Huang, Huang‑Pin Wu and Kuo‑Chin Kao. Dynamic driving pressure associated mortality in acute respiratory distress syndrome with extracorporeal membrane oxygenation. Annals of Intensive Care 2017 Jan;7(1):12. doi: 10.1186/s13613-017-0236-y.  

C91. Gee-Chen Chang, Chien-Hua Tseng, Kuo-Hsuan Hsu, Chong-Jen Yu, Cheng-Ta Yang, Kun-Chieh Chen, Tsung-Ying Yang, Jeng-Sen Tseng, Chien-Ying Liu, Wei-Yu Liao, Te-Chun Hsia, Chih-Yen Tu, Meng-Chih Lin, Ying-Huang Tsai, Meng-Jer Hsieh, Wen-Shuo Wu, Yuh-Min Chen*. Predictive factors for EGFR-tyrosine kinase inhibitor retreatment in patients with EGFR-mutated non-small-cell lung cancer – A multicenter retrospective SEQUENCE study.Lung Cancer 2017 Feb;104:58-64. doi: 10.1016/j.lungcan.2016.12.002.  

C92. Kuo-Chin Kao, Li-Chung Chiu, Chen-Yiu Hung,  Chih-Hao Chang, Cheng-Ta Yang, Chung-Chi Huang and Han-Chung Hu*. Coinfection and Mortality in Pneumonia-Related Acute Respiratory Distress Syndrome Patients with Bronchoalveolar Lavage: A Prospective Observational Study.Shock 2017 May;47(5):615-620.  

C93. Shih-Hong Li, Bor-Shing Lin, Chen-An Wang, Cheng-Ta Yang, Bor-Shyh Lin*. Design of wearable and wireless multi-parameter monitoring system for evaluating cardiopulmonary function. Medical Engineering and Physics 2017 Sep;47:144-150. doi: 10.1016/j.medengphy.2017.06.009. Epub 2017 Jul 3.  

C94. Hsu-Huei Weng, Kyle R. Noll, Jason M. Johnson, Sujit S. Prabhu, Yuan-Hsiung Tsai, Sheng-Wei Chang, Yen-Chu Huang, Jiann-Der Lee, Jen-Tsung Yang, Cheng-Ta Yang, Ying-Huang Tsai, Chun-Yuh Yang, John D. Hazle, Donald F. Schomer, Ho-Ling Liu*. Accuracy of presurgical functional MR imaging for language mapping of brain tumors: A systematic review and meta-analysis.Radiology 2017 Oct 4:162971. doi: 10.1148/radiol.2017162971.  

C95. Chin-Chou Wang, Chia-Cheng Tseng, Huang-Chih Chang, Kuo-Tung Huang, Wen-Feng Fang , Yu-Mu Chen, Cheng-Ta Yang, Chang-Chun Hsiao, Meng-Chih Lin, Chi-Kung Ho and Hon-Kan Yip*. Circulating microparticles are prognostic biomarkers in advanced non-small cell lung cancer patients.Oncotarget 2017 Jun 6;8(44):75952-75967. doi: 10.18632/oncotarget.18372. eCollection 2017 Sep 29.  

C96. Chih-Hao Chang, Chung-Shu Lee,  Shih-Hong Li, Fu-Tsai Chung, Chih-Wei Wang, Yu-Hsiang Juan, Han-Chung Hu, Li-Fu Li, Ning-Hung Chen, Cheng-Ta Yang, and Kuo-Chin Kao. Feasibility of Radial Endobronchial Ultrasound-Guided Bronchoscopic Cryobiopsy without Fluoroscopy for Lung Parenchymal Lesions.Canadian Respiratory Journal 2017;2017:7170687. doi: 10.1155/2017/7170687. Epub 2017 Nov 15.  


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